Q1321. weakness for 2 weeks. Complete blood count shows anemia and thrombocytopenia with marked leukocytosis. Peripheral blood smear reveals the following. Immunophenotyping demonstrates strong positivity for CD13 and CD33, while CD19 is negative. What is the most likely diagnosis?

Q1322. adolescence. On examination, he has pallor, frontal bossing, and hepatosplenomegaly. Laboratory investigations reveal hemoglobin of 7.5 g/dL with markedly reduced MCV and MCH. Peripheral blood smear reveals the following. What is the most likely underlying diagnosis responsible for these peripheral smear findings?

Q1324. A 50-year-old man presents with progressive weight loss, easy fatigability, and bleeding tendency. On examination, he has splenomegaly. Laboratory investigations show marked leukocytosis, peripheral smear with left shift and basophilia. What is the drug of choice for management of this condition?

Q1325. Patient complains of headache is being evaluated and found to have a brain tumor. HPE reveals tumor composed of Antoni A and B areas. Which among the following s an IHC marker positive in this tumor?

Q1327. A 7-year-old child presents with a rapidly enlarging jaw mass. The lymphoma is known to have a strong association with Epstein–Barr virus infection. Which of the following chromosomal translocations is most characteristic of this condition?

Q1329. Rheumatoid arthritis is primarily mediated by which type of hypersensitivity reaction?

Q1330. In COPD destruction of alveolar elastin is mediated by which of the following enzymes?

Q1331. A burn patient undergoes skin grafting. The cells responsible for rejuvenation and regeneration of the skin graft belong to which of the following categories?

Q1333. A 3-year-old child presents with upward slanting palpebral fissures, flat nasal bridge with developmental delay has the following facial features. What is the likely diagnosis? Image

Q1335. A kidney transplant recipient on long-term therapy presents with blisters and a non-healing ulcer on sun-exposed skin, which is diagnosed as squamous cell carcinoma. Which of the following factors is most likely responsible for the development of this malignancy?

Q1336. on WHO-MDT. After 2 months of regular treatment, he now presents with sudden onset of tender, erythematous, edematous lesions over the nose and forehead associated with mild fever. There is no new sensory loss or nerve tenderness. What is the most appropriate next step in management?

Q1337. A 26-year-old man diagnosed with diabetes insipidus was started on hydrochlorothiazide. The beneficial effect of hydrochlorothiazide in this patient is primarily due to which of the following mechanisms?

Q1338. Which of the following best describes the mechanism of action of gabapentin?

Q1339. Which of the following best describes the mechanism of action of colchicine in an acute attack of gout?

Q1341. started on ketoconazole. After 3–4 days of antifungal therapy, he complains of dizziness, severe fatigue, easy bruising,and repeated episodes of hypotension. His blood counts show new-onset thrombocytopenia and anemia. The most likely reason for these adverse effects is:

Q1342. A 28-year-old woman in her pregnancy is found to be HBsAg positive with high HBV DNA levels on routine antenatal screening. She has no features of liver failure. What is the most appropriate treatment during pregnancy?

Q1345. A female child is diagnosed with iron deficiency anemia and started on iron–folic acid tablets. The clinician also adds an additional vitamin to improve the efficacy of the therapy. Which regimen is most appropriately co-administered with iron–folic acid?

Q1346. A 28-year-old woman delivers a stillborn baby at 38 weeks of gestation. On the third postpartum day, she develops breast engorgement and painful fullness. The physician decides to pharmacologically suppress lactation. Which of the following drugs is most appropriate to decrease milk secretion?

Q1347. A 65-year-old woman with breast cancer was given combination chemotherapy including methotrexate. To reduce toxicity, leucovorin is administered. Which of the following enzymes is bypassed by leucovorin rescue during methotrexate therapy?