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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55714.Β Which out of the following antibiotics penetrates blood-CSF barrier the best

A.Erythromycin
B.Gentamicin
C.Tetracycline
D.Chloramphenicol

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Q55715.Β The most important mechanism by which gram negative bacilli acquire chloram- phenicol resistance is

A.Decreased permeability into the bacterial cell
B.Acquisition of a plasmid encoded for
C.Lowered affinity of the bacterial ribosome
D.Switching over from ribosomal to

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Q55716.Β What is the most important reason for restricted clinical use of chloramphenicol ?

A.Its narrow spectrum of activity
B.Emergence of chloramphenicol resistance
C.Its potential to cause bone marrow depression
D.Its potential to cause superinfections

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Q55717.Β Aminoglycoside antibiotics have the following common property

A.They are primarily active against gram-
B.They are more active in acidic medium
C.They readily enter cells and are distributed
D.They are nearly completely metabolized in

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Q55718.Β Which aminoglycoside antibiotic causes more hearing loss than vestibular disturabance as toxic effect ?

A.Streptomycin
B.Gentamicin
C.Kanamycin
D.Sisomicin

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Q55719.Β Which of the following drugs has demonstrated in vitro activity against Mycobacterium avium-intracellular (MAI)?

A.Vancomycin
B.Clarithromycin
C.Erythromycin base
D.Troleandomycin

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Q55720.Β The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is

A.Plasmid mediated acquisition of aminogly-
B.Mutational acquisition of aminoglycoside
C.Mutation reducing affinity of ribosomal
D.Mutational loss of porin channels

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Q55721.Β Which toxic effect of aminoglycoside antibiotics is most irreversible in nature ?

A.Vestibular damage
B.Hearing loss
C.Neuromuscular blockade
D.Kidney damage

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Q55722.Β Streptomycin sulfate is not absorbed orally because it is

A.Degraded by gastrointestinal enzymes
B.Destroyed by gastric acid
C.Highly ionized at a wide range of pH values
D.Insoluble in water

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Q55723.Β The aminoglycoside antibiotic which is distinguished by its resistance to bacterial aminoglycoside inactivating enzymes is

A.Kanamycin
B.Sisomicin
C.Amikacin
D.Tobramycin

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Q55724.Β An aminoglycoside antibiotic should not be used concurrently with the following drug

A.Ampicillin
B.Vancomycin
C.Ciprofloxacin
D.Rifampin

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Q55725.Β All of the following statements regarding pentamidine isethionate are true except

A.it is indicated for treatment or prophylaxis of
B.it may be administered intramuscularly,
C.it has no clinically significant effect on serum
D.it is effective in the treatment of leishmaniasis

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Q55726.Β Prolonged oral therapy with the following antibiotic can damage intestinal villi resulting in statorrhoea and loose motions

A.Ampicillin
B.Tetracycline
C.Neomycin
D.Nystatin

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Q55727.Β Hepatitits with cholestatic jaundice occurs most frequently as an adverse reaction to the following preparation of erythromycin

A.Erythromycin base
B.Erythromycin stearate
C.Erythromycin estolate
D.Erythromycin ethylsuccinate

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Q55728.Β The following antibiotic is a first line drug for treatment of Mycobacterium avium complex infection in AIDS patients

A.Clindamycin
B.Clarithromycin
C.Roxithromycin
D.Erythromycin

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Q55729.Β Roxithromycin has the following advantages over erythromycin except

A.It is more effective in whooping cough
B.It causes less gastric irritation
C.It has longer plasma half-life
D.It is unlikely to precipitate theophylline toxicity

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Q55730.Β Highest incidence of antibiotic associated pseudo membranous enterocolitis has been noted with the use of

A.Ampicillin
B.Chloramphenicol
C.Vancomycin
D.Clindamycin

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Q55731.Β The drug of choice for treatment of methicillin resistant Staphylococcus aureus infection is

A.Cloxacillin
B.Vancomycin
C.Erythromycin
D.Amikacin

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Q55732.Β β€˜Red man syndrome’ has been associated with rapid intravenous injection of the following antibiotic

A.Vancomycin
B.Clindamycin
C.Cefoperazone
D.Piperacillin

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Q55733.Β Clarithromycin is used for the following

A.Multidrug resistant M.tuberculosis infection
B.M.avium complex infection in AIDS patient
C.M.tuberculosis infection in a patient who
D.Both (a) and (b)

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