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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55654. The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called

A.Time-dependent killing
B.The post antibiotic effect
C.Clinical synergy
D.Concentration – dependent killing

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Q55655. In which of the following groups do all four drugs warrant careful monitoring for drug- related seizures in high-risk patients?

A.Penicillin G, imipenem, amphotericin B,
B.Penicillin G, chlormphenicol, tetracycline,
C.Imipenem, tetracycline, vancomycin,
D.Cycloserine, metronidazole, vancomycin,

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Q55656. Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes?

A.Ciprofloxacin
B.Cyclosporine
C.Erythromycin
D.Rifampin

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Q55657. Beta – lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G. which one of the following antibiotics is most likely to be effective against all strains of each of the above organisms?

A.Ampicillin
B.Ceftriaxone
C.Clindamycin
D.Gentamicin

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Q55658. A 19-year-old woman with recurrent sinusitis has been treated with different antibiotics on several occasions. During the course of one such treatment she developed a severe diarrhea and was hospitalized. Sigmoidoscopy revealed colitis, and pseudomembranes, were confirmed histologically. Which of the following drugs, administered orally, is most likely to be effective in the treatment of colitis due to C difficile?

A.Ampicillin
B.Cefazolin
C.Clindamycin
D.Metonidazole

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Q55659. Bleomycin is used in most effective drug combination regiment for the chemother- apy of testicular carcinoma. Which one of the following statements about the drug is accurate?

A.Acts mainly in the M phase of the cell cycle
B.Derived from the bark of yew trees
C.Myelosuppression is dose-limiting
D.Peripheral neuropathy occurs in more than

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Q55660. A high school student presents with head- ache, fever, and cough of 2 day’s dura- tion. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this patient appears to have atypical pneumonia. You should initiate treatment with

A.Cefazolin
B.Clindamycin
C.Erythromycin
D.Gentamicin

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Q55661. Chloramphenicol is particularly effective in the treatment of

A.Diphtheria
B.Tuberculosis
C.Emphysema
D.Rickettsial diseases

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Q55662. An advantage of bleomycin over most antineoplastic drugs is its

A.Rapid onset of action
B.Lack of toxicity to all normal cells
C.Relative lack of bone marrow toxicity
D.Very broad spectrum of activity

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Q55663. The drug of choice for scarlet fever is

A.Tetracycline
B.Sulfonamides
C.Penicillin
D.Chloromycetin

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Q55664. An advantge of betamethasone acetate over betamethasone sodium phosphate is

A.Fewer allergic reactions
B.Prompter action
C.More sustained action
D.Greater solubility

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Q55665. Cyclosporine is used for

A.Allergies
B.Angina
C.Prevention of transplant rejection
D.Steroid deficiency

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Q55666. The plasma half life of pencillin-G is longer in the new born because their

A.Plasma protein level is low
B.Drug metabolizing enzymes are immature
C.Glomerular filtration rate is low
D.Tubular transport mechanisms are not well

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Q55667. Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas

A.They are used to control diarrhoea irrespective
B.They should be used only as a short-term
C.They are used as adjuvants to antimicrobial
D.They are the drugs of choice in irritable bowel

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Q55668. Spectinomycin is an aminoglycoside-like antibiotic indicated for the treatment of

A.Gram-negative bacillary septicemia
B.Tuberculosis
C.Penicillin-resistant gonococcal infections
D.Syphilis

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Q55669. Select the antibiotic with a high therapeutic index

A.Streptomycin
B.Doxy
C.Cephalexin
D.Polymyxin B

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Q55670. Which of the following organisms is notorious for developing antimicrobial resistance rapidly ?

A.Streptococcus pyogenes
B.Meningococcus
C.Treponema pallidum
D.Escherichia coli

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Q55671. Widespread and prolonged used of an antibiotic leads to emergence of drug resistant strains because antibiotics

A.Induce mutation in the bacteria
B.Promote conjugation among bacteria
C.Allow resistant strains to propagate preferentially
D.All of the above

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Q55672. Of the following which is the most important mechanism of concurrent acquisition of multidrug resistance among bacteria ?

A.Mutation
B.Conjugation
C.Transduction
D.Transformation

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Q55673. Methicillin resistant staphylococci do not respond to β-lactam antibiotics because

A.They produce a β-lactamase which destroys
B.They elaborate an amidase which destroys
C.They have acquired a penicillin binding
D.They are less permeable to β-lactam antibiotics

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