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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55634.Β Which one of the following statements about cefotetan is accurate?

A.It is active against MRSA strains
B.It is the drug of choice in community-acquired
C.It is a fourth-generation cephalosporin
D.It decreases prothrombin time

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MCQs in PharmacologyDrugs Acting On Autonomous Nervous System
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55635.Β A patient needs antibiotic treatment for native valve, culture-positive infective enterococcal endocarditis. His medical history includes a severe anaphylactic reaction to penicillin G during the past year. The best approach would be treatment with

A.Amoxicillin/clavulanate
B.Aztreonam
C.Cefazolin plus genatamicin
D.Meropenem

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MCQs in Pharmacology
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55636.Β This drug has activity against many strains of Pseudomomas aeruginosa. However, when it is used alone, resistance has emerged during the course of treatment. The drug should not be used in penicillin- allergic patients. Its activity against gram- negative rods is enhanced if it is given in combination with tazobactam

A.Amoxicillin
B.Aztreonam
C.Imipenem
D.Piperacillin

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MCQs in Pharmacology
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Q55637.Β Which of the following statements about vancomycin is accurate?

A.It is bacteriostatic
B.It binds to PBPs
C.It is not susceptible to penicillinase
D.It has the advantage of oral bioavailability

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MCQs in Pharmacology
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Q55638.Β Which one of the following statements about ampicillin is false?

A.Its activity is enhanced by sulbactam
B.It causes maculopapular rashes
C.It is the drug of choice for Listeria mono-
D.It eradicates most strains of MRSA

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MCQs in Pharmacology
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55639.Β The mechanism of antibacterial action of tetracycline involves

A.Binding to a component of the 50S ribosomal
B.Inhibition of translocase activity
C.Blockade of binding of aminoacyl – tRNA to
D.Selective inhibition of ribosomal peptidyl

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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55640.Β Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it

A.Eradicates mycoplasmal infections in a single
B.Is active against strains of streptococci that
C.Is more active against Mycobacterium avium
D.Does not inhibit live drug-metabolizing enzymes

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Q55641.Β The primary mechanism underlying the resistance of gram-positive organisms to macrolide antibiotics is

A.Methylation of binding sites on the 50S
B.Formation of esterases that hydrolyze the
C.Increased activity of efflux mechanisms
D.Formation of drug-inactivating acetyltran-

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Q55642.Β The appearance of markedly vacuolated, nucleated red cells in the marrow, anemia, and reticulocytopenia are characteristic dose-dependent side effects of

A.Azithromycin
B.Chloramphenicol
C.Clindamycin
D.Doxycycline

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Q55643.Β In a patient with culture-positive entero- coccal endocarditis who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is

A.Clarithromycin
B.Erythromycin
C.Linezolid
D.Minocycline

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Q55644.Β All of the following factors may increase the risk of nephrotoxicity from gentamicin therapy except

A.age over 70 years
B.prolonged courses of gentamicin therapy
C.concurrent amphotericin B therapy
D.trough gentamicin levels below 2 mg/ml

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Q55645.Β Which one of the following antibiotics is likely to be most effective agent in the treatment of an infection due to enterococci if used in conjuction with penicillin G?

A.Amikacin
B.Gentamicin
C.Netilmicin
D.Streptomycin

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Q55646.Β Regarding the antibacterial action of gentamicin, which one of the following statements is most accurate?

A.Efficacy is directly proportionate to the time
B.The antibacterial action of gentamicin is not
C.Gentamicin continues to exert antibacterial
D.Antibacterial activity is often reduced by the

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Q55647.Β Which one of the following drugs is most likely to be effective against multidrug – resistant strains of M tuberculosis, including those resistant to streptomycin?

A.Amikacin
B.Clarithromycin
C.Gentamicin
D.Meropenem

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Q55648.Β Sterptomycin has no useful activity in the treatment of

A.Bubonic plague
B.Brucellosis
C.Lyme disease
D.Tuberculosis

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Q55649.Β Your 23-year-old female patient is pregnant and has gonorrhea. The past medical history includes anaphylaxis following exposure to amoxicillin. Worried about compliance, you would like to treat this patient with a singly dose, so you chose

A.Cefixime
B.Ceftriaxone
C.Ciprofloxacin
D.Spectinomycin

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Q55650.Β In the empiric treatment of severe bacterial infections of unidentified entiology, this drug, often used in combination with an aminoglycoside, provides coverage against many staphylococci

A.Amoxicillin
B.Clavulanic acid
C.Erythromycin
D.Nafcillin

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Q55651.Β Which one of the following statements about β€œone daily” dosing with aminogly- cosides is false ?

A.It is convenient for outpatient therapy
B.Adjustment of dosage is less important in
C.Less nursing time is required
D.It is often less toxic than conventional

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Q55652.Β Regarding the recently introduced lipid formulation of amphotericin B, which one of the following statements is accurate?

A.Affinity of amphotericin B for these lipids is
B.They are less expensive to use than conventional
C.They are more effective in fungal infections
D.They may decrease nephrotoxicity of

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Q55653.Β Which one of the following antimicrobial drugs does not require supplementation of dosage following hemodialysis?

A.Ampicillin
B.Cefazolin
C.Ganciclovir
D.Tobramycin

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MCQs in Pharmacology
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