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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55534.Β Which of the following drugs is a class III CARDIO–VASCULAR DRUGS 125 antiarrhythmic agent that is effective in the acute management of atrial fibrilla- tion or atrial flutter of recent onset ?

A.Bretylium
B.Lbutilide
C.Metoprolol
D.Disopyramide

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Q55535.Β Which of the following groups of symptoms is most often associated with a patient who has right-sided heart failure?

A.Nocturia, rales, paroxysmal nocturnal dyspnea
B.Paroxysmal nocturnal dyspnea, pedal edema,
C.Jugular venous distention, hepatojugular
D.Hepatojugular reflux, jugular venous

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Q55536.Β Which of the following combinations of drugs, when used together, reduce both preload and afterload?

A.Nitroglycerin and isosorbide dinitrate
B.Hydralazine and isosorbide dinitrate
C.Captopril and methyldopa
D.Prazosin and angiotension II

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Q55537.Β When digoxin is used in a patient with congestive heart failure (CHF), it works by exerting a positive effect on

A.Stroke volume
B.Total peripheral resistance
C.Heart rate
D.Blood pressure

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Q55538.Β Because of proven beneficial effects on β€œcardiac remodeling”, these agents are now indicated as first line therapy in CHF patients. Which of the following is representative of this group of drugs?

A.Hydrochlorothiazide
B.Enalapril
C.Furosemide
D.Carvedilol

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Q55539.Β For treating the patient with congestive heart failure (CHF), which of the following dosages of dopamine is selected for its positive inotropic effects?

A.2.0 mg/kg/min
B.5–10 mg/kg/min
C.10–20 mg/kg/min
D.40 mg/kg/min

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Q55540.Β Milrinone is an example of

A.Phosphodiesterase I inhibitor
B.Phosphodiesterase II inhibitor
C.Phosphodiesterase III inhibitor
D.Phosphodiesterase IV inhibitor

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Q55541.Β Situations that predispose a digitalis- treated patient to toxicity include

A.Hypercalcemia
B.Hyperkalemia
C.Hypermagnesemia

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Q55542.Β Unfractionated heparin binds to anti- thrombin III and inactivates clotting factor(s)

A.Xa
B.Ixa
C.Iia
D.All of the above

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Q55543.Β A patient to be commenced on oral anti- coagulant therapy for DVT would be treated with

A.Oral anticoagulant therapy with warfarin for
B.Oral anticoagulant therapy with warfarin for
C.Oral anticoagulant therapy with aspirin for

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Q55544.Β A patient on oral anticoagulant therapy is commenced on sulfamethoxazole- trimethoprim, double-strength twice daily. One may expect to see the international normalized ratio MCQs IN PHARMACOLOGY 126

A.Increase
B.Decrease
C.Remain unchanged

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Q55545.Β When compared to unfractionated heparin, low molecular weight heparins have

A.Preferential binding affinity to factor Xa
B.Shorter half-lives
C.Dose – dependent renal clearance

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Q55546.Β Acute renal failure (ARF) may be caused by all of the following except

A.Acute tubular necrosis (ATN) due to drug
B.Severe hypotension or circulatolry collapse
C.Decreased cardiac output, as from
D.Hemolysis, myoglobinuria

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Q55547.Β During Phase 2 of action potential in cardiac cell, depolarizing current through calcium channels is balanced by

A.Delayed rectifier potassium current
B.outward chloride channel
C.Both (a) and (b)
D.None of the above

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Q55548.Β The action of quinidine differs from that of digitalis in

A.Decreasing irritability of cardiac muscle
B.Preventing passage of impulses to the
C.Increasing irritability of heart muscle
D.Reducing conductivity

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Q55549.Β Overuse of digitalis may result in

A.Habituation
B.Tolerance
C.Addiction
D.Physical dependence

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Q55550.Β The action of digitalis is enhanced by

A.Sodium
B.Calcium
C.Magnesium
D.Potassium

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Q55551.Β In case of acute pain of angina pectoris the most effective treatment would be to administer

A.Mannitol hexanitrate
B.Erythrityl tetranitrate
C.Sodium nitrate
D.Pentaerythritol tetranitrate

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Q55552.Β Which of the following is used to lower blood lipid levels?

A.Trimethadione
B.Clofibrate
C.Flucytosine
D.Coumarin

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Q55553.Β The chief use of levoarterenol is to treat

A.Shock
B.Diabetes
C.Hypertension
D.Cardiac arrhythmias

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