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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55554. Tolerance to nitroglycerin may be overcome by

A.Initially using the largest safe dose of the drug
B.Using other nitrites
C.Temporarily discontinuing the drug for one
D.Use of higher doses

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Q55555. Quinidine can cause paradoxical tachy- cardia in a patient of

A.Stick sinus syndrome
B.Auricular extrasystoles
C.Auricular fibrillation
D.Ventricular extrasystoles

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Q55556. Quinidine is now used primarily for

A.Conversion of auricular fibrillation to sinus
B.Control of ventricular rate in atrial flutter
C.Termination of ventricular tachycardia
D.Prevention of recurrences of atrial and

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Q55557. Procainamide differs from quinidine in the following respect

A.It does not cause paradoxical tachycardia
B.It has no alfa adrenergic blocking activity
C.It has little antivagal action
D.Both (b) and (c)

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Q55558. In heart, potassium channels determine

A.Pacemaker function
B.Resting potential
C.Action potential duration
D.All of the above

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Q55559. Lidocaine is the preferred antiarrhythmic for emergency control of cardiac arrhyth- mias following acute myocardial infarction because

A.It has a rapidly developing and titratable
B.It casues little myocardial depression and
C.It has broad spectrum antiarrhythmic efficacy
D.Both (a) and (b)

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Q55560. Hypothyroidism is a possible consequence of prolonged therapy with

A.Procainamide
B.Mexiletine
C.Sotalol
D.Amiodarone

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Q55561. Which of the following drugs is preferred for termination of paroxysmal supraven- tricular tachycardia

A.Digoxin
B.Quinidine
C.Propranolol
D.Verapamil

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Q55562. The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack

A.Digoxin
B.Furosemide
C.Enalapril
D.Amrinone

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Q55563. Antianginal drugs afford the following benefit/benefits

A.Terminate anginal attacks
B.Decrease the frequency of anginal attacks
C.Retard the progression of coronary artery
D.Both (a) and (b)

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Q55564. Choose the correct statement about the action of nitrates on coronary vessels

A.They mitigate angina pectoris by increasing
B.They preferentially dilate conducting arteries
C.They preferentially dilate autoregulatory
D.They increase subepicardial blood flow

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Q55565. Organic nitrates relax vascular smooth muscle by

A.Increasing intracellular cyclic AMP
B.Increasing intracellular cyclic GMP
C.Decreasing intracellular cyclic AMP
D.Both (b) and (c)

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Q55566. Select the organic nitrate which undergoes minimal first-pass metabolism in the liver

A.Glyceryl trinitrate
B.Isosorbide dinitrate
C.Isosorbide mononitrate
D.Erythrityl tetranitrate

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Q55567. The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is

A.Increase in total coronary blood flow
B.Redistribution of coronary blood flow
C.Reduction of cardiac preload
D.Reduction of cardiac after load

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Q55568. Enhanced automaticity in cardiac cells may occur because of

A.β-adrenergic stimulation
B.Hypokalemia
C.Mechanical stretch of cardiac muscles
D.All of the above

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Q55569. Glyceryl trinitrate is administratered by all of the following routes except

A.Oral
B.Sublingual
C.Intramuscular
D.Intravenous

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Q55570. A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable.

A.Sublingual
B.Oral
C.Intravenous bolus injection
D.Slow intravenous infusion

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Q55571. A patient suffers from spisodic pain diffusely localized over the chest and upper abdomen, which is relieved by sublingual glyceryl trinitrate. He could be suffering from

A.Angina pectoris
B.Biliary colic
C.Esophageal spasm
D.All of the above

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Q55572. The dihydropyridines block the following type of calcium channels.

A.L-type voltage sensitive channels
B.T-type voltage sensitive channels
C.N-type voltage sensitive channels
D.Receptor operated calcium channels

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Q55573. Which of the following drugs is most likely to accentuate varient (Prinzmetal) angina ?

A.Digoxin
B.Furosemide
C.Enalapril
D.Amrinone

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