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PharmacologyGeneral
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Q55214. Passive diffusion of a drug across cell membrane is low when its molecular mass is greater than

A.50–100 Da
B.100–200 Da
C.200–300 Da
D.300–400 Da

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Q55215. Passage of drug across most capillary endothelial membranes is dependent upon

A.Lipid solubility
B.pH gradient
C.Blood flow
D.All of the above

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MCQs in PharmacologyGeneral
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Q55216. Following receptors are membrane proteins, except

A.Receptors for fast neurotransmitters, coupled
B.Receptors for many hormones and slow
C.Receptor for insulin and various growth
D.Receptors for steroid hormone

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MCQs in Pharmacology
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Q55217. pH difference between extracellular and intracellular fluid is

A.Nil
B.0.2
C.0.4
D.0.8

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Q55218. Which type of drugs penetrate CNS better

A.Lipid soluble
B.Weak acids
C.Weak bases
D.All equally

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MCQs in PharmacologyGeneral
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Q55219. Acidic drugs mostly bind to plasma

A.Albumin
B.Globulin
C.Glycoprotein
D.None of the above

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Q55220. The number of P 450 gene families identified in human being is

A.4
B.8
C.12
D.16

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MCQs in PharmacologyGeneral
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Q55221. The majority of drug biotransformation occurs by which cytochrome family

A.CYP1
B.CYP2
C.CYP3
D.None of the above

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Q55222. Nonlinearity in pharmacokinetics of a drug is due to saturation of

A.Protein binding
B.Hepatic metabolism
C.Active renal transport
D.All of the above

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Q55223. Which of the following disease is due to G protein receptor malfunction

A.Precocious puberty
B.Retinitis pigmentosa
C.Malignant hyperthyroidism
D.All of the above

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Q55224. The pharmacokinetic alternations in elderly are due to

A.Reduction in lean body mass and total body
B.Increase in percentage of body fat
C.Reduced cytochrome P450 enzymes
D.All of the above

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Q55225. The effect of enzyme induction is greatest when the drug is given

A.Digoxin
B.Furosemide
C.Enalapril
D.Amrinone

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Q55226. The hepatic enzyme inducer naringenin is present in

A.Tobacco smoke
B.Grape juice
C.Alcohol
D.Apple Juice

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Q55227. In gene tranfer which metal particle is often used

A.Iron
B.Gold
C.Platinum
D.Mobybdenum

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Q55228. Slow reacting substance of anaphylaxis refers to

A.LTC4
B.LTD4
C.Both of the above (d) None of the above

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Q55229. Drugs producing allergic reaction generally act as

A.Complete antigens
B.Haptens
C.Antibodies
D.Mediators

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Q55230. An addicting drug which produces little or no physical dependence is

A.Amphetamine
B.Methadone
C.Phenobarbitone
D.Diazepam

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Q55231. Which of the following statements regarding therapeutic window is correct ?

A.The ratio of LD50 to the ED50
B.The Dosage range between the minimum
C.Both the above
D.None of the above

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Q55232. Which of the following statements regarding acid –base balance is not correct ?

A.it is an essential balance between the amount
B.It must be kept constant so that the hydrogen
C.Any deviation in the balance can have a
D.All the above

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Q55233. During liver disease the metabolism and elimination of which of the following drugs is decreased

A.Morphine
B.Pentobarbitone
C.Propanolol
D.All the above

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MCQs in PharmacologyGeneral
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