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PharmacologyGeneral

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Q55174. First pass metabolism

A.Can increase the oral bio-availability of the

B.Occurs only in the liver

C.Is higher on intravenous administration

D.Necessitates high oral dose for certain drugs

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MCQs in PharmacologyGeneral

PharmacologyGeneral

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Q55175. Bio-transformation

A.Renders the drug more lipid soluble

B.Can be altered by drugs

C.Is necessary for all drugs for their elimination

D.Takes place only in the liver

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MCQs in PharmacologyGeneral

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Q55176. Entry of a drug in the central nervous system is enhanced if the drug is

A.Ionized

B.More lipid soluble

C.Given intravenously

D.Highly plasma protein bound

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MCQs in PharmacologyGeneral

PharmacologyGeneral

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Q55177. Kinetic processes of elimination for a large number of drugs is

A.First order

B.First order followed by zero order

C.Zero order followed by first order

D.Zero order

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MCQs in PharmacologyGeneral

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Q55178. A drug is said to be potent when

A.It produces maximal response

B.The amount needed to produce a certain

C.It produces minimal/no side effects

D.It has a rapid onset of action

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MCQs in PharmacologyGeneral

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Q55179. Spare receptors are often found among drugs that elicit

A.Smooth muscle contraction

B.Smooth muscle relaxation

C.Secretion

D.Cardiac stimulation

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MCQs in PharmacologyGeneral

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Q55180. What is the best criterian for judging the therapeutic superiority of a drug over its congeners?

A.Potency

B.Wide range of activity

C.Efficacy

D.Variability

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MCQs in PharmacologyGeneral

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Q55181. pKa of a compound

A.Is the pH of solution at which the compound

B.Is the pH of compound at which it is 50%

C.Is the time in which the compound is ionized

D.Is the time in which total compound is ionized

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MCQs in Pharmacology

PharmacologyGeneral

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Q55182. Pharmacokinetics is

A.The study of absorption, distribution,

B.The study of biological and therapeutic effects

C.The method of development of new

D.The study of carcinogenic activity of a new

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MCQs in PharmacologyGeneral

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Q55183. In which form the drug is absorbed more rapidly?

A.In aqueous solution

B.In suspension

C.In oily solution

D.In solid form

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Q55184. Alcohol is rapidly absorbed from the intestine because

A.It is lipid soluble and non-electrolyte

B.It is lipid soluble and highly ionised

C.It is absorbed by active transport

D.It is not absorbed quickly

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MCQs in Pharmacology

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Q55185. After intramuscular injection, the drugs

A.In oily solution are more rapidly absorbed

B.In aqueous solution are more rapidly

C.Suspended in various repository vehicles are

D.All solutions are rapidly absorbed

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MCQs in Pharmacology

PharmacologyGeneral

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Q55186. Bio-availability of a drug is

A.The percentage of drug released from a

B.The percentage of drug that is ionized from

C.The net amount of actual therapeutic agent

D.The dose of a drug by which 50% animals

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MCQs in Pharmacology

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Q55187. The absorption time of a drug can be reduced by

A.Making a more soluble salt – for oral

B.By using hyaluronidase – for injection

C.By using vesoconstrictor substances

D.By giving combination of drugs

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MCQs in Pharmacology

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Q55188. Reduction of heavy metal toxicity by dimercaprol is an exmple of

A.Chemical antagonist

B.Physiological antagonist

C.Pharmacokinetic antagonist

D.Antagonism by receptor block

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MCQs in PharmacologyGeneral

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Q55189. Which of the following drugs is primarily stored in the natural fat of the body

A.Primaquine

B.Acetyl salicylic acid

C.Thiopentone

D.Vitamin C

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Q55190. Bio-transformation of the drugs is to render them

A.Less lipid soluble

B.More protein bound

C.Less ionized

D.Less protein bound

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Q55191. Drug metabolism occurs chiefly in

A.Liver

B.Brain

C.Spleen

D.Kidneys

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Q55192. For renal excretion the factors important are

A.Extent of plasma protein binding of drugs

B.Glomerular filtration rate

C.Active renal tubular reabsorption

D.All of the above

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Q55193. If tubular urine is made more acid

A.Excretion of weak acid is reduced

B.Excretion of weak acid is increased

C.Excretion of weak base is increased

D.Excretion of weak base is reduced

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MCQs in PharmacologyGeneral

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