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PharmacologyGeneral
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Q55154.Β A drug β€˜R’ producing no response by itself causes the log dose-response curve of another drug β€˜S’ to shift to the right in a parallel manner without decreasing the maximal response : Drug β€˜R’ is a

A.Partial agonist
B.Inverse agonist
C.Competitive antagonist
D.Noncompetitive antagonist

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Q55155.Β A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a

A.Physiological antagonist
B.Competitive antagonist
C.Noncompetitive antagonist
D.Partial agonist

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MCQs in Pharmacology
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Q55156.Β A drug which is generally administered in standard doses without the need for dose individualization is

A.Insulin
B.Mebendazole
C.Prednisolone
D.Digoxin

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Q55157.Β A fixed dose combination preparation meant for internal use must not contain the following class of drug

A.Thiazide diuretic
B.Fluoroquinolone antimicrobial
C.Corticosteroid
D.H2 blocker

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MCQs in PharmacologyGeneral
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Q55158.Β Interindividual variations in equieffective doses of a drug are most marked if it is disposed by

A.glomerular filtration
B.Tubular secretion
C.Both (a) and (b)
D.Hepatic metabolism

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Q55159.Β The pharmacokinetics of drugs in the neonate differs from that in adults, because their

A.Intestinal transit is fast
B.Glomerular filtration rate is high
C.Tubular transport mechanisms are not well
D.Drug metabolizing enzymes are overactive

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MCQs in Pharmacology
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Q55160.Β Pharmacodynamic tolerance may involve changes in _____of drug receptors

A.Number
B.Affinity
C.Function
D.All the above

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Q55161.Β Drug metabolism can be induced by the following factors except

A.Cigarette smoking
B.Acute alcohol ingestion
C.Exposure to insecticides
D.Consumption of characoal boiled meat

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Q55162.Β Which of the following is true of placebos

A.Placebo is a dummy medication
B.Placebo is the inert material added to the
C.Placebos do not produce any effect
D.All patients respond to placebos

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Q55163.Β In patients of hepatic cirrhosis

A.The extent of change in pharmacokinetics of
B.High doses of furosemide can be safely used
C.Metformin is the preferred oral hypoglycaemic
D.Disposition of atenolol is not significantly

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MCQs in Pharmacology
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Q55164.Β An undersireable effect of a drug that occurs at therapeutic doses and can be predicted from its pharmacological actions is called

A.Side effect
B.Toxic effect
C.Allergic reaction
D.Idiosyncrasy

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MCQs in Pharmacology
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Q55165.Β Which of the following is a type II (unpredictable) adverse drug reaction

A.Side effect
B.Toxic effect
C.Idiosyncrasy
D.Physical dependence

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Q55166.Β A β€˜toxic effect’ differs from a β€˜side effect’ in that

A.It is not a pharmacological effect of the drug
B.It is a more intense pharmacological effect
C.It must involve drug induced cellular injury
D.It involves host defence mechanisms

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Q55167.Β Which of the following statements is true in relation to β€˜drug toxicity’ and β€˜poisoning’

A.The two terms are synonymous
B.When a toxic effect requires specific
C.A toxic effect which endangers life by
D.Toxicity is caused by drugs while poisoning

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Q55168.Β The most vulnerable period of pregnancy for the causation of foetal malformations due to drugs is

A.18–55 days of gestation
B.56–84 days of gestation
C.Second trimester
D.36 weeks onwards

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Q55169.Β Which of the following is a proven human teratogen

A.Chloroquine
B.Warfarin sodium
C.Dicyclomine
D.Methyldopa

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Q55170.Β Select the drug which has been found to be a strong human teratogen

A.Isoniazid
B.Isotretinoin
C.Hydralazine
D.Propylthiouracil

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Q55171.Β Oral route

A.Yields better absorption than parenteral
B.Should be avoided in the recumbent position
C.Has no demerit
D.Produces quick onset of action

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Q55172.Β Intramuscular route

A.Always produces faster absorption than oral
B.Can be used to inject mild irritants
C.In a child is made into the gluteus maximus
D.Can be used to inject a volume of 15 ml

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Q55173.Β Advantage of sublingual route include the following except

A.It has a rapid onset of action
B.Spitting out the tablet can terminate its action
C.Its usefulness is limited to treat local conditions
D.It avoids first pass hepatic metabolism

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MCQs in Pharmacology
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