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Q1566. A 50-year-old farmer from Tamil Nadu presents with multiple draining sinuses over the foot. Examination shows black granules discharging from the sinuses. KOH mount demonstrates fungal hyphae. Imaging shows no bone involvement. What is the most appropriate management?

A.Prolonged antibiotic therapy alone
B.Surgical debridement with antifungal therapy
C.Immediate amputation of the limb
D.Klebsiella granulomatis

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FMGE2025Repeats: N/A
MedicineRespiratory
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Q1567. A 10-year-old child presents with intense itching that worsens at night. There is a history of bronchial asthma. On examination, there are ill-defined, erythematous, excoriated plaques over the flexural areas. What is the most likely diagnosis?

A.Psoriasis
B.Atopic dermatitis
C.Seborrheic dermatitis
D.Antitubercular therapy

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DermatologyInflammatory
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Q1569. A Female patient presents with grouped vesicular lesion on upper lip, with target lesion around extremities as seen in the clinical picture. What is the most likely diagnosis?

A.Erythema multiforme
B.Bullous pemphigoid
C.Dermatoses herpetiformis
D.Pemphigus vulgaris

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PharmacologyGeneral Pharmacology
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Q1573. A young patient experiences shortness of breath specifically during exercise in winter, which subsides after using salbutamol. What is the most likely explanation for this condition?

A.Influx of Na ions
B.Efflux of Na ions
C.Efflux of K ions
D.Airway hyperreactivity due to cold-induced asthma exacerbation

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BiochemistryVitamins & Minerals
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Q1575. Which Vitamin deficiency can cause lactic acidosis?

A.Niacin
B.Riboflavin
C.Pantothenic acid
D.Thiamine

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AnatomyNeuroanatomy
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Q1577. Which among the following hormones, in lactating mother is responsible for the growth of breast tissue?

A.Oxytocin
B.Estrogen
C.Prolactin
D.Progesterone

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AnatomyThorax & Abdomen
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Q1578. Which among the following best describes 'Neuropraxia'?

A.Intact axon; Damaged nerve sheath
B.Damaged axon; Intact nerve sheath
C.Damaged axon and nerve sheath
D.None of the above

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AnatomyNeuroanatomy
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Q1579. A woman from Delhi travels to Ladakh, a high-altitude region. Soon after arrival, she develops symptoms such as breathlessness, headache, and lightheadedness. What is the primary underlying mechanism responsible for her symptoms?

A.Increased sodium influx into the muscle cell
B.Metabolic acidosis
C.Respiratory alkalosis
D.Respiratory acidosis

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BiochemistryNucleotide Metabolism
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Q1580. In malignant hyperthermia, a genetic mutation in the ryanodine receptor (RYR1) leads to a life-threatening reaction to certain anesthetic agents. What is the primary ionic abnormality caused by this receptor defect?

A.Nucleotide excision repair
B.Mismatch repair
C.Base excision repair
D.Increased calcium release from the sarcoplasmic reticulum

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BiochemistryLipid Metabolism
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Q1582. A man presents with elevated VLDL and chylomicrons, along with eruptive xanthomas. What is the most likely diagnosis?

A.Familial hyperlipidemia
B.Familial dysbetalipoproteinemia
C.Familial hypertriglyceridemia
D.Familial hypercholesterolemia

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BiochemistryCarbohydrate Metabolism
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Q1583. A breastfed infant presents with lethargy, hepatomegaly, and cataracts. Which enzyme deficiency is most likely responsible for this presentation?

A.Galactokinase
B.G6PD
C.Aldolase B
D.Fructokinase

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BiochemistryVitamins & Minerals
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Q1585. A family consumes a diet predominantly composed of rice and pulses and has developed signs of muscle weakness and movement issues. Which of the following supplements should be given prophylactically?

A.Calcium
B.Thiamine
C.Vitamin D
D.Iron

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BiochemistryCarbohydrate Metabolism
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Q1586. Which of the following acts as a major intracellular antioxidant and helps detoxify reactive oxygen species?

A.Glutathione
B.Catalase
C.Superoxide dismutase
D.Peroxidase

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PsychiatryMood Disorders
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Q1587. vomiting, and poor feeding following prolonged fasting. Laboratory results show hypoglycemia, low ketone levels (hypoketosis), and mild hepatomegaly. These findings suggest a defect in fat metabolism. What is the most likely underlying disorder?

A.Carbamoyl phosphate synthetase I deficiency
B.Ornithine transcarbamylase (OTC) deficiency
C.Orotidine 5'-phosphate decarboxylase deficiency
D.Argininosuccinate lyase deficiency

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BiochemistryVitamins & Minerals
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Q1588. A 2-month-old infant presents with poor feeding, vomiting, and lethargy. Laboratory studies reveal hyperammonemia and elevated levels of orotic acid in the urine. Which enzyme deficiency is most likely?

A.Vitamin B12 deficiency
B.Folic acid deficiency
C.Orotidine 5'-phosphate decarboxylase deficiency
D.Argininosuccinate lyase deficiency

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MedicineHematology Medicine
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Q1589. reveal megaloblastic anemia. Further metabolic testing shows elevated serum homocysteine and decreased plasma cysteine levels. Serum methylmalonic acid is normal. There are no neurological symptoms.Which of the following is the most likely cause of his condition?

A.Dizygotic twins
B.Monozygotic twins
C.Adopted
D.Siblings from consanguineous marriage

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PathologyGeneral Pathology
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Q1598. HPV most commonly causes which of the following head and neck cancers?

A.Oral cancer
B.Laryngeal cancer
C.Esophageal cancer
D.Oropharyngeal cancer

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PathologyHematopathology
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Q1601. symptoms like fever and weight loss. Lymph node biopsy reveals large atypical lymphoid cells. Genetic studies show a chromosomal translocation commonly seen in anaplastic large cell lymphoma. Choose the correct translocation is seen in this condition?

A.Antemortem Negri bodies
B.Viral culture
C.Immunological assay
D.Samples from the nape of the neck

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MicrobiologyVirology
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Q1602. A woman presents to the clinic 2 weeks after being bitten by a dog. The dog died 1 week after the bite. She is concerned about potential rabies infection. How can the rabies virus be detected in this patient?

A.Ehlers-Danlos syndrome
B.Viral culture
C.Immunological assay
D.Samples from the nape of the neck

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PathologyGeneral Pathology
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Q1604. The tumor suppressor protein p53 promotes apoptosis by increasing the expression of which of the following pro-apoptotic genes?

A.Bax
B.Bcl-2
C.Bcl-xL
D.Mcl-1

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