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BiochemistryNucleic Acids
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Q51820. De novo synthesis of pyrimidine nucle- otides is regulated by

A.Carbamoyl phosphate synthetase
B.Aspartate transcarbamoylase
C.Both (A) and (B)
D.None of these

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51821. Cytosolic carbamoyl phosphate synthe- tase is inhibited by

A.UTP
B.CTP
C.PRPP
D.TMP

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51822. Cytosolic carbamoyl phosphate syn- thetase is activated by

A.Glutamine
B.PRPP
C.ATP
D.Aspartate

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51823. Aspartate transcarbamoylase is inhibited by

A.CTP
B.PRPP
C.ATP
D.TMP

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51824. The following cannot be salvaged in hu- man beings:

A.Cytidine
B.Deoxycytidine
C.Cytosine
D.Thymidine

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51825. β -Aminoisobytyrate is formed from ca- tabolism of

A.Cytosine
B.Uracil
C.Thymine
D.Xanthine

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51826. Free ammonia is liberated during the catabolism of

A.Cytosine
B.Uracil
C.Thymine
D.All of these

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51827. β -Alanine is formed from catabolism of

A.Thymine
B.Thymine and cytosine
C.Thymine and uracil
D.Cytosine and uracil

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51828. The following coenzyme is required for catabolism of pyrimidine bases:

A.NADH
B.NADPH
C.FADH2
D.None of these

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51829. Inheritance of primary gout is

A.Autosomal recessive
B.Autosomal dominant
C.X-linked recessive
D.X-linked dominant

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51830. The following abnormality in PRPP synthetase can cause primary gout:

A.High Vmax
B.Low Km
C.Resistance to allosteric inihbition.
D.All of these

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MCQs in BiochemistryNucleic Acids
BiochemistryNucleic Acids
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Q51831. All the following statements about primary gout are true except

A.Its inheritance is X-linked recessive
B.It can be due to increased activity of PRPP
C.It can be due to increased activity of hypox-
D.De novo synthesis of purines is increased in it

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MCQs in Biochemistry
BiochemistryNucleic Acids
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Q51832. All of the following statements about uric acid are true except

A.It is a catabolite of purines
B.It is excreted by the kidneys
C.It is undissociated at pH above 5.8
D.It is less soluble than sodium urate

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MCQs in Biochemistry
BiochemistryNucleic Acids
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Q51833. In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase

A.De novo synthesis of purine nucleotides is
B.Salvage of purines is decreased
C.Salvage of purines is increased
D.Synthesis of uric acid is decreased

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MCQs in Biochemistry
BiochemistryNucleic Acids
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Q51834. All of the following statements about uric acid are true except

A.It can be formed from allantoin
B.Formation of uric acid stones in kidneys can
C.Uric acid begins to dissociate at pH above 5.8
D.It is present in plasma mainly as monosodium

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MCQs in Biochemistry
BiochemistryNucleic Acids
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Q51835. All of the following statements about primary gout are true except

A.Uric acid stones may be formed in kidneys
B.Arthritis of small joints occurs commonly
C.Urinary excretion of uric acid is decreased
D.It occurs predominantly in males

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MCQs in Biochemistry
BiochemistryNucleic Acids
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Q51836. All of the following statements about allopurinol are true except

A.It is a structural analogue of uric acid
B.It can prevent uric acid stones in the kidneys
C.It increases the urinary excretion of xanthine
D.It is a competitive inhibitor of xanthine oxidase

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MCQs in Biochemistry
BiochemistryNucleic Acids
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Q51837. Orotic aciduria can be controlled by

A.Oral administration of orotic acid
B.Decreasing the dietary intake of orotic acid
C.Decreasing the dietary intake of pyrimidines
D.Oral administration of uridine

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MCQs in Biochemistry
BiochemistryNucleic Acids
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Q51838. All of the following occur in orotic aciduria except

A.Increased synthesis of pyrimidine nucleotides
B.Increased excretion of orotic acid in urine
C.Decreased synthesis of cytidine triphosphate
D.Retardation of growth

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MCQs in Biochemistry
BiochemistryNucleic Acids
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Q51839. Inherited deficiency of adenosine deami- nase causes

A.Hyperuricaemia and gout
B.Mental retardation
C.Immunodeficiency
D.Dwarfism

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MCQs in BiochemistryNucleic Acids
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