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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55494.Β If the patient has a history of gout, which of the following drugs is most likely to exacerbate this condition?

A.Colestipol
B.Gemfibrozil
C.Lovastatin
D.Niacin

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MCQs in PharmacologyDrugs Acting On Autonomous Nervous System
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55495.Β After being counseled about lifestyle and dietary changes, the patient was started on atorvastatin. During his treatment with atorvastatin, it is important to routinely monitor serum concentrations of

A.Blood urea nitrogen (BUN)
B.Alanine and aspartate aminotransferase
C.Platelets
D.Red blood cells

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MCQs in Pharmacology
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55496.Β Six months after beginning atorvastatin, the patient’s total and LDL cholesterol concentrations remained above normal and he continued to have anginal attacks despite good adherence to his antianginal medications. His physician decided for niacin. The major recognized mechanism of action of niacin is

A.Decreased lipid synthesis in adipose tissue
B.Decreased oxidation of lipids in endothelial
C.Decreased secretion of VLDL by the liver
D.Increased endocytosis of HDL by the liver

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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55497.Β Following drugs act on imidazoline receptor

A.Moxonidine
B.Dexmedetomidine
C.Tizanidine
D.All of the above

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MCQs in PharmacologyDrugs Acting On Autonomous Nervous System
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55498.Β Which one of the following drugs increase digoxin plasma concentration by a pharmacokinetic mechanism?

A.Captopril
B.Hydrochorothiazide
C.Lidocaine
D.Quinidine

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MCQs in Pharmacology
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55499.Β A 55-year-old patient currently receiving other drugs for another condition is to be started on diuretic therapy for mild heart failure. Thiazides are known to reduce the excretion of

A.Diazepam
B.Fluoxetine
C.Imipramine
D.Lithium

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MCQs in Pharmacology
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55500.Β A hypertensive patient has been using nifedipine for some time without unto- ward effects. If he experiences a rapidly developing enhancement of the antihyper- tensive effect of the drug, it is probably due to

A.Concomitant use of antacids
B.Fods containing tyramine
C.Grapefruit juice
D.Induction of drug metabolism

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MCQs in Pharmacology
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Q55501.Β A drug lacking vasodilator properties that is useful in angina is

A.Isosorbide dinitrate
B.Metoprolol
C.NIfedipine
D.Nitroglycerin

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Q55502.Β Aldosterone release is stimulated by

A.Angiotensin I
B.Angiotensin
C.Angiotensin III
D.Both (b) and (c)

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MCQs in PharmacologyDrugs Acting On Autonomous Nervous System
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55503.Β Which one of the following drugs is used in the treatment of male impotence and activates prostaglandin E1 receptors?

A.Alprostadil
B.Fluoxetine
C.Mifepristone
D.Sildenafil

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MCQs in Pharmacology
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55504.Β A treatment of angina that consistently decreases the heart rate and can prevent vasospastic angina attacks is

A.Isosorbide dinitrate
B.NIFedipine
C.Nitroglycerin
D.Propranolol

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Q55505.Β In a patient receiving digoxin for congestive heart failure, condition that may facilitate the appearance of toxicity include

A.Hyperkalemia
B.Hypernatremia
C.Hypocalcemia
D.Hypomagnesemia

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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55506.Β Activation of endothelin receptor ETA, leads to

A.Vasoconstriction
B.Bronchoconstriction
C.Aldosterone release
D.All of the above

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MCQs in PharmacologyDrugs Acting On Autonomous Nervous System
PharmacologyDrugs Acting On Autonomous Nervous System
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Q55507.Β Methylxanthine drugs such as aminophyl- line cause which one of the following?

A.Vasoconstriction in many vascular beds
B.Decrease in the amount of cAMP in mast
C.Bronchodilation
D.Activation of the enzyme phosphodiesterase

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Q55508.Β Drugs used in asthma that often cause tachycardia and tremor include

A.Beclomethasone
B.Cromolyn sodium
C.Ipratropium
D.Metaproterenol

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MCQs in PharmacologyDrugs Acting On Autonomous Nervous System
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Q55509.Β Following potassium sparing diuretic inhibits action of aldosterone

A.Amiloride
B.Triamterene
C.Spironolactone
D.All of the above

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Q55510.Β In patients with chronic granulomatous disease which of the following agents increases the synthesis of tumor necrosis factor, leading to activation of phagocy- tosis?

A.Aldesleukin
B.Cyclosporine
C.Filgrastim
D.Infliximab

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Q55511.Β The mechanism of action of cyclosporine involves

A.Activation of calcineurin
B.Binding to cyclophilin to cause inhibition of
C.Blockade of interleukin – 2- receptors
D.Inhibition of phospholipase A2

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Q55512.Β Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility?

A.Digoxin
B.Lidocaine
C.Propranolol
D.Quinidine

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Q55513.Β Which of the following is the drug of choice for management of cardiac arrhythmias that occur in digitalis toxicity?

A.Amiodarone
B.Lidocaine
C.Propranolol
D.Sotalol

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MCQs in Pharmacology
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