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PharmacologyGeneral
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Q55254. Excipients are

A.Pharmacologically inert substances
B.Used to mask an unpleasant taste
C.Used to increase solubility or stability to the
D.Employed to add bulk to the active agent

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Q55255. Bio-assay is used to

A.Determine the relationship between the dose
B.Determine the potency of a new agent
C.Determine the relationship between the doses
D.All the above

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Q55256. Which of the following endogenous compounds undergo methylation ?

A.Histamine
B.Estradiol
C.Thyroxine
D.All the above

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Q55257. Which one of the following statements regarding glucuronide conjugation is not correct

A.The most frequently occurring reactions
B.The conjugating agent is glucuronic acid,
C.The glucuronide are rapidly eliminated in the
D.The glucuronides are also secreted in the bile,

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Q55258. Which of the following therapeutic sys- tems provides continuous, unattended, controlled drug input for a long period without gastrointestinal or hepatic drug inactivation prior to systemic circulation ?

A.Parenteral
B.Oral
C.None of the above
D.All the above

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Q55259. The translocation of a solute from one side of a biologic barrier to the other side and the transferred solute appearing in the same form on both side of the biological barrier is known as

A.Bioavailability
B.Biotransport
C.Bioequivalence
D.None of the

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Q55260. Guanine nucleotides bind to the ______ subunit of G-proteins

A.α
B.β
C.γ
D.All the above

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Q55261. Pharmacodynamics include

A.The biological effects produced by chemicals
B.The site/s and mechanism by which the
C.The factors that effect the safety and
D.All the above

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Q55262. The person who set forth the principles that drugs are effective only after reaching a responsive tissue and that there is a relationship between the structure of drugs and the effects that they produce

A.Paracelsus
B.William Harvey
C.James Blake
D.Rudolf Buccheim

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Q55263. The great scientist who explained the circulation of the blood to the world which signaled of the beginning of the scientific study of the medical sciences was

A.Paracelsus
B.William Harvey
C.James Blake
D.Rudolf Buccheim

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Q55264. All the below mentioned drugs cause enzyme inhibition in man except one

A.Acetazolamide
B.Allopurinol
C.Meprobamate
D.Disulfiram

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Q55265. All the below mentioned drugs cause enzyme induction in man except one

A.Phenytoin
B.Phenobarbitone
C.Griseofulvine
D.Enalapril

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Q55266. Cimetidine potentiates the action of propranol, theophylline, warfarin and phenytoin because

A.It causes deficiency of G - 6–PD
B.It blocks the H2 – histaminergic receptors
C.It is an inhibitor of microsomal P–450
D.None of the above

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Q55267. The incidence of adverse drug reaction rises with age in the adult, especially after 65 years because of

A.The increasing number of drugs they need
B.Poor compliance with dosing regimens
C.Bodily changes of aging that require
D.All the above

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Q55268. Agranulocytosis is

A.Virtual absence from the blood of white cells
B.It is a life-threatening conditions that results
C.Can be treated with antibiotics and
D.All the above

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Q55269. Characteristically following oral admin- istration to a man, drugs

A.Are absorbed readily when in the unionized
B.Are absorbed primarily in the intestine
C.Cross membranes mainly by simple diffusion
D.With high lipid solubility readily penetrate

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Q55270. Competitive antagonists

A.Dissociate from receptors faster than their
B.Alter the shape of the log dose response
C.According to the rate theory have low
D.Initiate the opposite cellular response to

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Q55271. A non-competitive antagonist

A.Alters the mechanism of action of an agonist
B.Alters the potency of an agonist
C.Shifts the dose-response curve of an agonist
D.Decreases the maximum response to an

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Q55272. Repeated administration of a drug may

A.Increase its own metabolism
B.Increase the metabolism of other drugs
C.Increase the metabolism of endogenous
D.All the above

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Q55273. Plasma concentration is useful for

A.Drugs with high safety margin
B.Drugs with low safety margin
C.Drugs activated in the body
D.Hit and run drugs

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