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PharmacologyGeneral
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Q55054.Β What equation describes the rate of drug dissolution from a tablet?

A.Fick’s law
B.Henderson – Hasselbach equation
C.Law of mass action
D.Michaelis – Menten equation

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Q55055.Β Dose dumping is a problem in the formulation of

A.Compressed tablets
B.Modified- release drug products
C.Hard gelatin capsules
D.Soft gelatin capsules

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Q55056.Β The rate of drug bioavailability is most rapid when the drug is formulated as a

A.Controlled – release product
B.Hard gelatin capsule
C.Compressed tablet (d) Solution

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Q55057.Β Creatinine clearance is used as a mea- surement of

A.Renal excretion rate
B.Glomerular filtration rate (GFR)
C.Active renal secretion
D.Passive renal absorption

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Q55058.Β The earliest evidence that a drug is stored in tissue is

A.An increase in plasma protein binding
B.A large apparent volume of distribution (VD)
C.A decrease in the rate of formation of
D.An increase in the number of side effects

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Q55059.Β The intensity of the pharmacologic action of a drug is most dependent on the

A.Concentration of the drug at the receptor site
B.Elimination half-life (tΒ½ ) of the drug
C.Onset time of the drug after oral
D.Minimum toxic concentration (MTC) of the

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Q55060.Β Drug that show nonlinear pharmacoki- netics have which property?

A.A constant ratio of drug metabolites is formed
B.The elimination half-life (tΒ½) increases as the
C.The area under the plasma drug
D.Both low and high doses follow first-order

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Q55061.Β The loading dose (DL) of a drug is usually based on the

A.Total body clearance (ClT) of the drug
B.Percentage of drug bound to plasma proteins
C.Fraction of drug excreted unchanged in the urine
D.Apparent volume of distribution (VD) and

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Q55062.Β The renal clearance of insulin is used as a measurement of

A.Effective renal blood flow
B.Rate of renal drug excretion
C.Intrinsic enzyme activity
D.Active renal secretion

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Q55063.Β All of the following statements about plasma protein binding of a drug are true except

A.Displacement of a drug from plasma protein
B.Displacement of a drug from plasma protein
C.Displacement of a potent drug that is normally
D.Albumin is the major protein involved in

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Q55064.Β _______ is expressed in both the intestinal epithelium and the kidney.

A.CYP2D6
B.CYP1A1/2
C.CYP3A4
D.CYP2E1

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Q55065.Β The initial distribution of a drug into tissue is determined chiefly by the

A.Rate of blood flow to tissue
B.Glomerular filtration rate (GFR)
C.Stomach emptying time
D.Affinity of the drug for tissue

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Q55066.Β Which tissue has the greatest capacity to bio-transform drugs?

A.Brain
B.Kidney
C.Liver
D.Lung

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Q55067.Β The principle of superposition in designing multiple-dose regimens assumes that

A.Each dose affects the next subsequent dose
B.Each dose of drug is eliminated by zero-order
C.Steady-state plasma drug concentration are
D.Early doses of drug do not affect subsequent

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Q55068.Β Which equation is true for a zero-order reaction rate of drug ?

A.dA/dt = - k
B.tΒ½ = 0.693/k
C.A = A0e -kt

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Q55069.Β Which of the following functional groups is most susceptible to hydrolysis ?

A.R – CO – R
B.R – COOR
C.R – O - R
D.R – NH- CH3

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Q55070.Β Monomer units of proteins are known as

A.Monosaccharides (b) Prosthetic groups
B.Amino acids
C.Purines

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Q55071.Β Glucose is a carbohydrate that cannot be hydrolyzed into a simpler substance. It is best described as

A.A sugar
B.A monosaccharide
C.A disaccharide
D.A polysaccharide

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Q55072.Β All of the following carbohydrates are considered to be polysaccharides except

A.Heparin
B.Starch
C.Glycogen
D.Maltose

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Q55073.Β Which of the following compounds are considered the building blocks of nucleic acids ?

A.Nucleotides
B.Nucleosides
C.Monosaccharides (d) Purines

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