MCQ Book Questions

Q55014. With regard to clinical trials of new drugs, which of the following is most correct ?

Q55015. Animal testing of potential new therapeutic agents GENERAL PHARMACOLOGY 3

Q55016. The “dominant lethal” test involves the treatment of a male adult animal with a chemical before mating; the pregnant female is later examined for fetal death and abnormalities. The dominant lethal test therefore is a test of

Q55017. The Ames test is a method for detecting

Q55018. “Nicotinic” sites include all of the following except

Q55019. A good example of chemical antagonism

Q55020. Which of the following agents is a pro- drug that is much less toxic in mammals than in insects ?

Q55021. Phenylephrine causes

Q55022. Pretreatment with propranolol will block which one of the following ?

Q55023. Most drug receptors are

Q55024. With regard to distribution of a drug from the blood into tissues

Q55025. The pH value is calculated mathematically as the

Q55026. Which property is classified as colligative?

Q55027. The colligative properties of a solution are related to the

Q55028. The pH of a buffer system can be calculated with the

Q55029. Which mechanism is most often responsible for chemical degradation?

Q55030. Which equation is used to predict the stability of a drug product at room temperature from experiments at accelerated temperature?

Q55031. Based on the relation between the degree of ionization and the solubility of a weak acid, the drug aspirin (pKa 3.49) will be most soluble at

Q55032. The particle size of the dispersed solid in a suspension is usually greater than

Q55033. In the extemporaneous preparation of a suspension, levigation is used to