Q1239. A 40- year-old patient came with complaints of spikes of fever and difficulty in breathing. Trancesophageal echo found out vegetations in the heart. The culture showed positive for Burkholderia cepacia. Which of the following is the first line management? Drug of choice for Burkholderia cepacia pneumonia is?

Q1317. receptors. The hormone–receptor complex then translocates to the nucleus and binds to specific DNA sequences to regulate gene transcription. Which of the following DNA- binding motifs enables steroid hormone receptors to attach to their target sites on DNA?

Q1324. A 50-year-old man presents with progressive weight loss, easy fatigability, and bleeding tendency. On examination, he has splenomegaly. Laboratory investigations show marked leukocytosis, peripheral smear with left shift and basophilia. What is the drug of choice for management of this condition?

Q1338. Which of the following best describes the mechanism of action of gabapentin?

Q1339. Which of the following best describes the mechanism of action of colchicine in an acute attack of gout?

Q1341. started on ketoconazole. After 3–4 days of antifungal therapy, he complains of dizziness, severe fatigue, easy bruising,and repeated episodes of hypotension. His blood counts show new-onset thrombocytopenia and anemia. The most likely reason for these adverse effects is:

Q1349. What is the mechanism of action of finasteride?

Q1351. A 35-year-old man undergoes renal transplantation. To avoid nephrotoxicity associated with calcineurin inhibition, his physician plans to use an immunosuppressant that specifically inhibits IL-2–mediated T-cell proliferation without blocking calcineurin. Which of the following drugs is most appropriate?

Q1358. A patient with bronchial asthma is prescribed a salbutamol metered dose inhaler (MDI). He has difficulty coordinating actuation with inspiration, so his physician advises the use of a spacer device with the MDI. Which of the following statements is true regarding the use of a spacer with an MDI?

Q1413. Which statistical test is most appropriate for comparing cholesterol levels within a single group 300 patient before and after administering a drug in 3 month time?

Q1541. A patient is given 5 mg IV morphine for postoperative pain management. You are monitoring him for opioid toxicity. Which of the following findings can suggest morphine overdose?

Q1573. A young patient experiences shortness of breath specifically during exercise in winter, which subsides after using salbutamol. What is the most likely explanation for this condition?

Q1619. Which of the following is used as an abortive treatment for cluster headcahes?

Q1624. Which of the following is a correct drug regimen for the treatment of Helicobacter pylori infection?

Q1627. A pregnant woman presents with headache and decreased vision. MRI reveals a pituitary macroadenoma compressing the optic chiasma. What is the drug of choice to manage this patient?

Q1641. A patient presents with a painful black eschar with surrounding edema over the abdomen. He reports a recent trip to a forested area, he is unable to take oral medications due to severe nausea and vomiting. Which of the following is the most appropriate drug for initial treatment?

Q1651. A lady with her 10-month-old baby presents to the doctor, stating there is no BCG vaccination mark on the baby. However, the doctor checks the vaccination card and confirms the baby was vaccinated, and the Mantoux test is positive. What is the next step?

Q1675. A whole family consuming Bajra roti now presents to the clinic with complaints of nausea, vomiting, and diarrhea. What is the most likely cause?

Q1966. A male patient with chronic obstructive pulmonary disease (COPD) was prescribed