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Q1337. A 26-year-old man diagnosed with diabetes insipidus was started on hydrochlorothiazide. The beneficial effect of hydrochlorothiazide in this patient is primarily due to which of the following mechanisms?

A.Direct stimulation of V2 receptors in the collecting duct
B.Inhibition of Na
C.Blocking aquaporin-2 channels in the collecting duct
D.Increasing medullary interstitial osmolarity

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Q1343. A 32-year-old man returned from a malaria-endemic area with high-grade fever for 5 days. On examination, he is drowsy, confused, and has altered sensorium. Peripheral smear shows Plasmodium falciparum. What is the most appropriate treatment?

A.Intravenous artesunate
B.Intravenous artesunate with sulfadoxine–pyrimethamine
C.Oral artemether–lumefantrine
D.Acyclovir

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Q1344. A 25-year-old man returns from Manipur with high-grade fever and chills for 3 days. Peripheral smear shows Plasmodium falciparum trophozoites. What is the most appropriate treatment?

A.Artemether–lumefantrine (AL) for 3 days + single-dose primaquine on Day 2
B.Artemether–lumefantrine (AL) for 3 days + primaquine for 14 days
C.Chloroquine for 3 days + primaquine single dose
D.Oral quinine for 7 days

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Q1346. A 28-year-old woman delivers a stillborn baby at 38 weeks of gestation. On the third postpartum day, she develops breast engorgement and painful fullness. The physician decides to pharmacologically suppress lactation. Which of the following drugs is most appropriate to decrease milk secretion?

A.Oxytocin
B.Misoprostol
C.Adrenaline
D.Bromocriptine

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Q1356. 22-year-old man diagnosed with enteric fever (typhoid) was started on ciprofloxacin. After 5 days of therapy, he continues to have high-grade fever and toxic symptoms. Blood culture later confirms Salmonella typhi. What is the most appropriate next drug of choice?

A.Chloramphenicol
B.Ampicillin
C.Vancomycin alone
D.Clindamycin

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Q1360. presents on day 7 of his treatment cycle with dysuria, suprapubic pain, and frank hematuria.Urine examination shows numerous red blood cells without infection. It is diagnosed as hemorrhagic cystitis. His current chemotherapy regimen includes the following agents. Which drug is most likely responsible for his symptoms?

A.Ifosfamide
B.Vincristine
C.Methotrexate
D.Doxorubicin

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Q1365. 20-year-old college student presents with fever, sore throat, and cervical lymphadenopathy. Peripheral blood smear shows atypical lymphocytes. The Paul–Bunnell heterophile antibody test is positive. What is the most likely causative organism?

A.Cytomegalovirus
B.Epstein–Barr virus
C.Human immunodeficiency virus
D.Intracellular gram-negative bacillus

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Q1372. d) Toxoplasma gondii A 32-year-old unmarried man is brought reporting recurrent sexual arousal by wearing women’s clothes. The behavior has been present since adolescence and is associated with sexual gratification. The most appropriate diagnosis is

A.Fetishism
B.Transsexualism
C.Eonism
D.Homosexuality

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Q1376. A 30-year-old man is brought for medico-legal evaluation. He gives a history of being unable to perform sexual intercourse only with his wife, while he has normal erectile function with other females. There is no history of systemic illness or substance abuse. What is the most likely cause of his condition?

A.Quoad hoc
B.Ejaculatory failure
C.Erectile dysfunction
D.Urolagmia

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Q1377. A 35-year-old man wishes to donate a kidney to his brother. According to the Transplantation of Human Organs and Tissues Act (THOTA / Human Organ Donation Act, India), which of the following is required for the procedure?

A.Written consent of the donor alone is sufficient
B.Only attainment of the legally prescribed donor age is required
C.Compatibility of blood group alone is adequate
D.Informed written consent of the donor along with approval from

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Q1381. 52-year-old chronic smoker presents with long-standing hoarseness of voice. Laryngoscopic reveals the following. The most likely diagnosis is:

A.Vocal cord nodule
B.Vocal cord polyp
C.Reinke’s edema
D.Laryngeal papillomatosis

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Q1384. 52-year-old diabetic patient with poorly controlled blood glucose presents with facial pain, nasal blockage, and a black necrotic lesion over the nasal turbinate (black sinus) along with fever. Imaging shows involvement of the maxillary sinus. What is the most appropriate management?

A.Surgical debridement only
B.Surgical debridement with antifungal therapy
C.Surgical debridement with antibiotics
D.Antibiotics only

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Q1386. 40-year-old patient presents with chronic nasal crusting, epistaxis, nasal obstruction, and saddle-nose deformity. There is a history of recurrent sinusitis. The most likely underlying diagnosis is:

A.Relapsing polychondritis
B.Granulomatosis with polyangiitis
C.Atrophic rhinitis
D.Nasal septal hematoma

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Q1387. 40 year old female presents with change in voice and hoarseness. On laryngeal examination soft tissue mass lesion is seen involving one vocal cord, the vocal cord is limited mobility. What is the treatment of choice?

A.Radiotherapy alone
B.Total laryngectomy
C.Atrophic rhinitis
D.Nasal septal hematoma

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Q1388. for 6 months. On examination: Rinne test is positive in both ears (AC > BC) Weber test lateralizes to the left ear What is the most likely diagnosis?

A.Left conductive hearing loss
B.Right sensorineural hearing loss
C.Right conductive hearing loss
D.Chemoradiation

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Q1394. An audiogram demonstrates air–bone gaps in both ears, with bone-conduction thresholds around 30 dB and air-conduction thresholds around 41 dB across tested frequencies. What is the most likely type of hearing loss?

A.Bilateral conductive hearing loss
B.Bilateral sensorineural hearing loss
C.Mixed hearing loss with greater
D.Bilateral mixed hearing loss

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Q1396. A hearing assessment chart displays air-conduction and bone-conduction thresholds plotted across different frequencies (Hz) on the X-axis and hearing level in decibels (dB) on the Y-axis. Which of the following investigations is being depicted?

A.Tympanometry
B.Brainstem evoked response audiometry
C.Otoacoustic emissions
D.Pure tone audiometry

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Q1400. A 13-year-old girl presents to the eye clinic with her mother requesting LASIK urgery. Which of the following is a contraindication for LASIK?

A.Age less than 13 years
B.Central corneal thickness less than 480 microns
C.Refractive error of 4 D myopia
D.Stable refractive error for one year

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Q1421. In a study, 500 women used a contraceptive method for 6 months each. During this period, 4 accidental pregnancies occurred. What is the Pearl Index for this contraceptive method?

A.8
B.4
C.0.8
D.1.6

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Q1423. A researcher conducts a survey by calling people, asking about their physical activity levels and whether they have any heart disease at that point in time. Which type of study is this?

A.Observational cohort study
B.Case-control study
C.Cross-sectional study
D.Reduce the number of beneficiaries to 20 and match logistics

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