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PhysiologyGeneral Physiology
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Q11373. 30 years old came with complaints of easy fatigability, exertional dyspnea, and weight loss. She also complains of frequent falls. physical examination revealed there was a bilateral decrease in vibration sense. Her hemoglobin levels were 8.2g%. She was treated with folate. Her anemia improved but neurological symptoms worsened. Which of the following is the most probable reason for her condition?

A.Folate not absorbed
B.Unmasked pyridoxine deficiency
C.Deficiency of folate reductase in CNS
D.Folate therapy caused rapid use of Vit B12 stores aggravating

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PathologyGeneral Pathology
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Q11374. A 45-year-old man who is a chronic smoker came to the clinic with a complaint of cough. The physician examines the patient and takes a biopsy, the picture in the biopsy was as the description below. Which of the following cellular changes has happened to this patient?

A.Hyperplasia
B.Dysplasia
C.Metaplasia
D.CIN3

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SurgeryGeneral Surgery
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Q11375. A 30-year-old woman presents with thyroid swelling. On investigations, her TSH levels are found to be elevated. Postoperative reports showed lymphocytic infiltration and hurthle cells. A most probable diagnosis is?

A.Graves disease
B.Hashimoto's thyroiditis
C.Follicular carcinoma
D.Medullary carcinoma thyroid

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PathologyGeneral Pathology
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Q11376. Which of the following will be seen on cardiac biopsy of a patient who had a post MI reperfusion injury?

A.Waviness of fibres
B.Eosinophilic contraction bands
C.Neutrophils in cardiac cells
D.Swelling of cells

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PsychiatryMood Disorders
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Q11377. Loss of foot process is classical in case of?

A.Membranous glomerulitis
B.Segmental glomerulosclerosis
C.IgA nephropathy
D.Diabetic nephropathy

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MedicineNeurology
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Q11378. Which of the following factors play a major role in the initiation of thrombus formation?

A.Vasoconstriction
B.Coagulation cascade activation
C.Platelets activation
D.Endothelial injury

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PathologyImmunopathology
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Q11379. A 33-year-old man presents with a 5-week history of calf pain, swelling, and low- grade fever. Serum levels of creatinine kinase are elevated. A muscle biopsy reveals numerous eosinophils also she had peripheral blood eosinophilia. Which of the following interleukins is primarily responsible for the increase in eosinophils in this patient?

A.IL 2
B.IL 4
C.IL 1
D.IL6

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MicrobiologyVirology
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Q11380. Which of the following is true about PAN?

A.Microscopy shows fibrinoid necrosis in large arteries
B.ANCA is positive
C.30% of people have HbsAg positive
D.Patient have hypogammaglobulinemia

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ENTEar
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Q11381. A 23-year-old male presented with a history of fatigue and tiredness. On investigation, he was found to have Hb values of 9gm%, MCV of 101 FL. peripheral smear examination showed microcytic RBC and hypersegmented neutrophils. Which is most probable etiology

A.Lead poisoning
B.Iron deficiency anemia
C.Chronic alcoholism
D.Hemolytic anemia

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PsychiatryMood Disorders
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Q11382. What is the main feature of chemotaxis as observed in white blood cells?

A.Increased random movement of neutrophils
B.Increased adhesiveness to intima
C.Increased phagocytosis
D.Unidirectional locomotion of neutrophils

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PharmacologyGeneral Pharmacology
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Q11383. Which of the following anticancer drugs are competitive inhibitors of tyrosine kinase –

A.Imatinib and sunitinib
B.Letrozole
C.Bicalutamide
D.Fulvestrant

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PharmacologyAntimicrobials
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Q11384. Which is not a prokinetic agent?

A.Dopamine antagonist
B.5HT4 agonist
C.Macrolides
D.Diphenylmethane

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BiochemistryNucleotide Metabolism
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Q11385. Which of the following drugs act by inhibiting DNA replication?

A.6 Mercaptopurine
B.Actinomycin D
C.Mitomycin C
D.Asparaginase

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PharmacologyCardiovascular Drugs
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Q11386. DOC for Onychomycosis?

A.Terbinafine
B.Fluconazole
C.Nystatin
D.Itraconazole

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RadiologyGeneral Radiology
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Q11387. Theophylline by what mechanism causes diuresis?

A.PDE3 inhibition
B.PDE4 inhibition
C.Beta 2 agonist action
D.Adenosine A1 receptor antagonism

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MedicineRespiratory
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Q11388. Which of the following antimicrobials should not be given to a chronic asthmatic patient managed on theophylline therapy?

A.Erythromycin
B.Amoxicillin
C.Cefotaxime
D.Cotrimoxazole

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PharmacologyAutonomic Pharmacology
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Q11389. DOC of prophylaxis for motion sickness?

A.Promethazine
B.Prochlorperazine
C.Metoclopramide
D.Itopride

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PharmacologyCardiovascular Drugs
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Q11390. Which of the following antihypertensive drug is avoided in patients with high serum uric acid levels?

A.Hydrochlorothiazide
B.Enalapril
C.Prazosin
D.Atenolol

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MicrobiologyBacteriology
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Q11391. Mechanism of resistance to penicillins via beta-lactamase is

A.Altered penicillin-binding proteins
B.Drug efflux
C.Breaks drug structure
D.Alteration in 50S ribosome structure

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PharmacologyCardiovascular Drugs
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Q11392. A patient on lithium therapy developed hypertension. He was started on Thiazide for hypertension. After a few days, he developed coarse tremors and other symptoms suggestive of lithium toxicity. What is the probable mechanism of interaction?

A.Thiazide increases the tubular reabsorption of lithium
B.Thiazide inhibits the metabolism of lithium
C.Thiazides act as an add on the drug to lithium
D.All of the above

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