Q1329. Rheumatoid arthritis is primarily mediated by which type of hypersensitivity reaction?

Q1330. In COPD destruction of alveolar elastin is mediated by which of the following enzymes?

Q1331. A burn patient undergoes skin grafting. The cells responsible for rejuvenation and regeneration of the skin graft belong to which of the following categories?

Q1333. A 3-year-old child presents with upward slanting palpebral fissures, flat nasal bridge with developmental delay has the following facial features. What is the likely diagnosis? Image

Q1335. A kidney transplant recipient on long-term therapy presents with blisters and a non-healing ulcer on sun-exposed skin, which is diagnosed as squamous cell carcinoma. Which of the following factors is most likely responsible for the development of this malignancy?

Q1336. on WHO-MDT. After 2 months of regular treatment, he now presents with sudden onset of tender, erythematous, edematous lesions over the nose and forehead associated with mild fever. There is no new sensory loss or nerve tenderness. What is the most appropriate next step in management?

Q1337. A 26-year-old man diagnosed with diabetes insipidus was started on hydrochlorothiazide. The beneficial effect of hydrochlorothiazide in this patient is primarily due to which of the following mechanisms?

Q1338. Which of the following best describes the mechanism of action of gabapentin?

Q1339. Which of the following best describes the mechanism of action of colchicine in an acute attack of gout?

Q1341. started on ketoconazole. After 3–4 days of antifungal therapy, he complains of dizziness, severe fatigue, easy bruising,and repeated episodes of hypotension. His blood counts show new-onset thrombocytopenia and anemia. The most likely reason for these adverse effects is:

Q1342. A 28-year-old woman in her pregnancy is found to be HBsAg positive with high HBV DNA levels on routine antenatal screening. She has no features of liver failure. What is the most appropriate treatment during pregnancy?

Q1343. A 32-year-old man returned from a malaria-endemic area with high-grade fever for 5 days. On examination, he is drowsy, confused, and has altered sensorium. Peripheral smear shows Plasmodium falciparum. What is the most appropriate treatment?

Q1344. A 25-year-old man returns from Manipur with high-grade fever and chills for 3 days. Peripheral smear shows Plasmodium falciparum trophozoites. What is the most appropriate treatment?

Q1345. A female child is diagnosed with iron deficiency anemia and started on iron–folic acid tablets. The clinician also adds an additional vitamin to improve the efficacy of the therapy. Which regimen is most appropriately co-administered with iron–folic acid?

Q1346. A 28-year-old woman delivers a stillborn baby at 38 weeks of gestation. On the third postpartum day, she develops breast engorgement and painful fullness. The physician decides to pharmacologically suppress lactation. Which of the following drugs is most appropriate to decrease milk secretion?

Q1347. A 65-year-old woman with breast cancer was given combination chemotherapy including methotrexate. To reduce toxicity, leucovorin is administered. Which of the following enzymes is bypassed by leucovorin rescue during methotrexate therapy?

Q1348. of 15000 ft. Within 18–24 hours of arrival, he develops throbbing headache, nausea, dizziness, fatigue, and difficulty sleeping. His pulse is 104/min, respiratory rate is 22/min, and SpO2 is 88% on room air. There are no focal neurological deficits and no signs of pulmonary edema. The best immediate management of his condition is:

Q1349. What is the mechanism of action of finasteride?

Q1350. The primary mechanism of action of botulinum toxin is?