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PharmacologyDrugs Acting On Autonomous Nervous System
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Q55414.Β The site of action of d-tubocurarine is

A.Spinal internuncial neurone
B.Motor nerve ending
C.Muscle end-plate
D.Sodium channels in the muscle fiber

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MCQs in PharmacologyDrugs Acting On Autonomous Nervous System
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Q55415.Β The fall in blood pressure caused by d- tubocuranine is due to

A.Reduced venous return.
B.Ganglionic blockade
C.Histamine release
D.All of the above

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MCQs in PharmacologyDrugs Acting On Autonomous Nervous System
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Q55416.Β The neuromuscular blocker having prominent antivagal action is

A.Pancuronium
B.Vecuronium
C.Atracurium
D.Gallamine triethiodide

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Q55417.Β Neuromuscular blocking drugs do not produce central actions because

A.Nicotinic receptors are not present in the
B.They do not cross the blood-brain barrier
C.They are sequestrated in the periphery by
D.They do not ionize at the brain pH

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Q55418.Β Pancuronium differs from tubocurarine in that

A.It is a depolarizing blocker
B.Its action is not reversed by neostigmine
C.It can cause rise in BP on rapid I.V. injection
D.It causes marked histamine release

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MCQs in Pharmacology
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Q55419.Β Muscarinic receptors are G-protein coupled receptors, causing

A.Inactivation of phospholipase C
B.Activation of adenylyl cyclase
C.Activation of potassium or inhibition of
D.All of the above

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Q55420.Β Postoperative muscle soreness may be side effect of the following neuromuscular blocker

A.d-tubocurarine
B.Succinylcholine
C.Pancuronium
D.Atracurium

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Q55421.Β Following drug enhances the evoked release of acetylcholine

A.4-aminopyridine
B.Vesamicol
C.Magnesium ion
D.None of the above

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Q55422.Β Which of the following muscle relaxants can be used to control spasticity associated with upper motor neurone paralysis ?

A.d-tubocurarine
B.Succinylcholine
C.Mephenesin
D.Baclofen

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Q55423.Β Following muscarinic agonist is suscepti- ble to hydrolysis by cholinesterase

A.Carbachol
B.Methacholine
C.Bethanechol
D.Muscarine

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Q55424.Β Dihydroergotamine differs from ergota- mine in the following respect

A.It is a more potent oxytocic
B.It has antiemetic property
C.It is a less potent a adrenergic blocker but
D.It is a more potent a adrenergic blocker and

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Q55425.Β Select the ergot compound which is primarily used for dementia

A.Bromocriptine
B.Ergotamine
C.Codergocrine
D.Methysergide

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Q55426.Β The β€˜amine’ ergot alkaloid differs from β€˜amino acid’ ergot alkaloids in that it has

A.High oral bioavailability
B.Better CNS penetrability
C.Weaker oxytocic action
D.Strong anti – 5 – HT action

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Q55427.Β Select the correct statement in relation to drug therapy of migraine

A.Simple analgesics like paracetamol are
B.Ergot alkaloids are used for the prophylaxis
C.Use of ergot alkaloids is restricted to severe
D.Ergot alkaloids should be given till 24 hours

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Q55428.Β Ergotamine relieves migraine by

A.Blocking vascular a adrenergic receptors
B.Blocking vascular 5-HT2 receptors
C.Dilating cranial arterio-venous shunt channels
D.Constricting cranial vessels and reducing

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Q55429.Β Which of the following drugs is most com- monly used for prophylaxis of migraine ?

A.Ergotamine
B.Propranolol
C.Methysergide
D.Sumatripitan

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Q55430.Β Stimulation of exocrine glands by muscarinic agonist leads to

A.Sweating
B.Salivation
C.Bronchial secretions
D.All of the abvoe

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Q55431.Β Datura stramonium (thorn apple) mainly contains following muscarinic antagonist

A.Atropine
B.Hyoscine
C.Homatropine
D.Dicyclomine

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Q55432.Β Ξ²-blockers are contraindicated in

A.Prophylaxis of anxiety states
B.Hyperthyroidism
C.Hypertrophic obstructive cardiomyopathy
D.Peripheral vascular disease

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Q55433.Β Ξ²-blockers are better avoided in

A.Bronchial astham
B.Pheochromocytoma
C.Myocardial infarction
D.Migraine

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